hrp0095p2-70 | Diabetes and Insulin | ESPE2022

Familial Genetic Syndrome of Severe Insulin Resistance and Hyperandrogenemia in a young girl with Polycystic Ovary Morphology

Patriciu Zubascu Gheorghita , Florina Predescu Andrada , Maria Stancu Ana , Tarna Mihaela , Nicoleta Cima Luminita , Alnuaimi Osama , Tincuta Petca Aida , Plaiasu Vasilica , Fica Simona , plate and mineral metabolism growth

Introduction: Signs of hyperandrogenemia are common through adolescent and young females, hirsutism affecting 5% of reproductive -aged women. The most common cause of hyperandrogenemia and insulin resistance (IR) is polycystic ovary syndrome (PCOS) (1). The differential diagnosis includes congenital adrenal hyperplasia (CAH) (2), androgen secreting tumors, but also very rare genetic syndromes of IR.Case report: A 13 year...

hrp0095p2-214 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Central precocious puberty - an unusual paraneoplastic manifestation of a nephroblastoma?

Stancu Ana-Maria , Gheorghita Zubascu Patriciu , Iliescu Marina , Tarna Mihaela , Andrei Marian , Comsa Codruta , Antonie Lavinia , Nicoleta Cima Luminita , Fica Simona

Introduction: Nephroblastoma or Wilms tumor is the most common pediatric abdominal malignancy. Typically, it is found in children younger than 5 years old, girls being more likely to have Wilms tumor than boys. The etiology of the disease is genetic, due to alteration in the development of the genitourinary tract.[1] Treatment is represented by surgery (unilateral nephrectomy), chemo- and radio-therapy. Paraneoplastic endocrine disorders may occur, but there a...